Argo™ Alanylglutamine Powder

What is Argo?

ArgoTM Alanylglutamine is a nutritional supplement containing a stable, water-soluble dipeptide comprised of the amino acids L-Glutamine and L-Alanine, with potential protective and absorption enhancing activities. Upon oral or enteral administration, Alanylglutamine works locally in the gastrointestinal (GI) tract to both protect the integrity of the intestinal mucosa and maintain intestinal barrier functions. This reduces bacterial translocation, the risk of infection, infection-induced inflammatory damage and infection-associated symptoms, such as diarrhea, dehydration, malabsorption and electrolyte imbalances. Alanylglutamine also increases absorption of other chemicals, enhances epithelial repair, and inhibits apoptosis due to cellular damage, and stimulates cellular proliferation. Altogether, this improves absorption of nutrients, decreases weight loss, reduces diarrhea, decreases the risk of GI-associated infections and improves recovery. Upon absorption, Alanylglutamine may also help inhibit muscle protein catabolism. [1]

Advantage

– Freely soluble and clear in water

– Stable in liquids and with other nutrients

 

Reference

[1] NCIT https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C127908

Description

Why Argo?

Bioavailability: Argo is more bioavailable than L-Glutamine and maybe more efficiently absorbed [5,6,7].

Solubility and Stability: Argo is freely soluble and clever in water. Argo is stable in liquids and with other nutrients in varies formulation.

L-Glutamine: Glutamine is the most abundant free amino acid in the body. Amino acids are the building blocks of protein. Glutamine is produced in the muscles and is distributed by the blood to the organs that need it. Glutamine might help gut function, the immune system, and other essential processes in the body, especially in times of stress. It is also important for providing “fuel” (nitrogen and carbon) to many different cells in the body. Glutamine is needed to make other chemicals in the body such as other amino acids and glucose (sugar).

How Argo works on your Cell?

– Alanylglutamine is absorbed by Pept-1 dipeptide transporter in the intestines and colon [2,3,4]. According to clinical trial [5], human under fasted conditions, Alanylglutamine is better absorbed than equivalent.

– Alanylglutamine appears to be more metabolized by the kidney than the liver when compared to the free amino acids, which are heavily metabolized by the liver.

– Several papers have indicated that glutamine is a preferred fuel for the enterocyte and that it can increase intestinal epithelial cell proliferation.

How is Argo Produced?

Argo is manufactured in a strictly GMP facility with highly implemented quality control and quality assurance procedure to ensure the purity of the Argo. Argo is a highly stable, water soluble product with more bioavailable than L-Glutamine alone. Argo is allergen-free, vegetarian, tasteless, odorless which makes Argo a great ingredients choice for food, drink, dietary supplements formulated to support cell nutrition and enhance body performance.

 

Reference

[2] Adibi S.A. The oligopeptide transporter (Pept-1) in human intestine: biology and function, Gastroenterology. 1997 Jul; 113(1):332-40.

[3] Alteheld B. et al. Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells, J Nutr. 2005 Jan;135(1):19-26.

[4] Ford. D. et al. Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption. Histochem Cell Biol. 2003 Jan;119(1):37-43. Epub 2002 Dec 10.

[5] Harris R.C. et al. L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein. Nutr Res. 2012 Apr;32(4):272-7.

[6]Lima A. A. et al. Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. Nutrition. 2002 Jun;18(6):458-62.

[7]Thwaites D. T. et al. H/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na/H exchanger. Gastroenterology. 2002 May;122(5):1322-33.

Additional information

Specification

Product name: L-Alanyl-L-glutamine
INCI Name: Alanyl Glutamine
CAS Number: 39537-23-0
Formula: C8H15N3O4
Molecular weight: 217.22

Specifications:
Appearance: White or off-white crystal or crystalline powder
Odor and taste: Odorless, no taste
Loss on drying : Not more than 0.5%
pH: 5.0 to 6.0
Specific rotation: +9.5o to +11.0o
Chloride (Cl): Not more than 0.02%
Ammonium (NH4): Not more than 0.02%
Sulfate (SO4): Not more than 0.02%
Methanol: Not more than 0.3%
Toluene: Not more than 0.089%
Assay (HPLC): 98.5%~101.5% (on dried basis)
Total Aerobic Microbial Count: Not more than 10 cfu/g
Total Yeasts/Molds Count : Not more than 10 cfu/g
E. Coli: Absent
Heavy metal: Less than 10 ppm
Arsenic: Not more than 1 ppm

Solubility:
Freely soluble in water, insoluble in ethanol, in acetone or in either
Storage condition:
Store at 15oC to 30oC in tight, light resistant containers
Packaging:
Standard packing 25 kg/barrel

About US

Since 2013, Davidia provided specialized ingredient to enhance product bioavailability, increase the function of the ingredients and help nutrition absorption for the body. We provide high quality product developed under highly quality control process from research lab to commercial products. We are also able to offer a full package of bioavailability tests (In vitro, ex vivo and in vivo test), technical data (specification, test method, QA/QC data, toxicity evaluation, and science literature), regulatory support (NDI, GRAS, label claim), and custom formulation support.

Contact US

Davidia Healthtech, LLC
6335 Nancy Ridge Dr. Suite 2B
San Diego, CA 92121 USA
Tel: +1 858 666 1288
Cell:+1 858 610 7316
Email: Info@davidiahealthtech.com
www.davidiahealthtech.com
www.davidiaglobal.com

FDA disclaimer

These statements have not been evaluated by the Food and Drug Administration. Those products are not intended to diagnose, treat, cure, or prevent any disease.

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